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Description

(2) Advantages Over Synthetics : Natural agonists often exhibit fewer gastrointestinal side effects and additional benefits (e.g., anti-inflammatory, lipid-lowering), though their efficacy and half-life are inferior to drugs like semaglutide

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doi:10.1158/0008-5472.CAN-13-0755

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The clinical trial data showed that using a lower starting dose (2 mg vs 4 mg initial) significantly reduced the incidence and severity of these symptoms

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